Results 1 to 2 of 2
  1. #1
    Join Date
    Jul 2015
    Location
    Mid Atlantic
    Posts
    1,289
    Thanks (Given)
    1663
    Thanks (Received)
    2307
    Likes (Given)
    589
    Likes (Received)
    576
    Mentioned
    45 Post(s)
    Rep Power
    14505780

    Default Possible Antibody treatment for Covid Virus

    Possible Antibody treatment for Covid Virus


    Therapeutics company Sorrento has made what it believes could be a breakthrough in potential treatment of SARS-CoV-2, the virus that leads to COVID-19. The company released details of its preclinical research on Friday, announcing that it has found an antibody that provides “100% inhibition of SARS-CoV-2 virus infection of healthy cells after four days incubation.” The results are from a preclinical study that still has to undergo peer review. It was an in vitro laboratory study (meaning not in an actual human being), but it’s still a promising development as the company continues to work on production of an antibody “cocktail” that could provide protection against SARS-CoV-2 even in case of mutations in the virus.


    Sorrento says it believes this antibody, which is labelled STI-1499, stood out among billions of candidates it has been screening from its extensive human antibody library for its ability to completely block the interaction of the SARS-CoV-2’s spike protein with a human cell target receptor. That means it prevents the virus from attaching to the host’s healthy cell, which is what leads to incubation and infection.


    The nature of the antibody’s efficacy means that Sorrento currently believes it will be the first antibody to be included in the cocktail it is developing, which will be made up of a large number of different antibodies that show efficacy in blocking the attachment of the spike protein, in order to provide multiple avenues of protection that are designed to remain effective even if the virus mutates in transmission from person to person, or within the same individual. One of the big outstanding questions that researchers are working on answering currently is just how mutagenic SARS-CoV-2 actually is, as many coronaviruses like the common cold show a tendency to mutate pretty quickly, rendering long-lasting cures and treatments difficult to develop.


    Sorrento’s COVID-SHIELD is meant to address this through a potent mix of different antibodies that provide protection against different strains of the virus, but the company says it also will be pursuing development of the STI-1499 antibody on its own as a dedicated, standalone therapy. The company is already in discussion with regulators about how to expedite development of that potential treatment, and is ramping its production capacity as well with the goal of producing as many as one million doses at the same time it pursues FDA approval for its use.


    It’s definitely worth cautioning that no treatment or vaccine is likely to be a “magic bullet” in treating SARS-CoV-2 or COVID-19, but this is still a promising development, and one to watch as it undergoes clinical trials and the therapeutic development and regulatory process.



    https://techcrunch.com/2020/05/15/sorrento-finds-a-coronavirus-antibody-that-blocks-viral-infection-100-in-preclinical-lab-experiments/
    Wise men don't need advice, and fools won't take it - Ben Franklin
    You may not be interested in war, but war may be interested in you - Leon Trotsky
    It's not how you start, it's how you finish.

  2. Thanks Kathianne, Gunny, Tyr-Ziu Saxnot, Abbey thanked this post
    Likes Kathianne, Tyr-Ziu Saxnot, Abbey liked this post
  3. #2
    Join Date
    May 2012
    Location
    USA, Southern
    Posts
    24,770
    Thanks (Given)
    28066
    Thanks (Received)
    16012
    Likes (Given)
    1957
    Likes (Received)
    1695
    Mentioned
    53 Post(s)
    Rep Power
    21475181

    Default

    Quote Originally Posted by Russ View Post
    Possible Antibody treatment for Covid Virus


    Therapeutics company Sorrento has made what it believes could be a breakthrough in potential treatment of SARS-CoV-2, the virus that leads to COVID-19. The company released details of its preclinical research on Friday, announcing that it has found an antibody that provides “100% inhibition of SARS-CoV-2 virus infection of healthy cells after four days incubation.” The results are from a preclinical study that still has to undergo peer review. It was an in vitro laboratory study (meaning not in an actual human being), but it’s still a promising development as the company continues to work on production of an antibody “cocktail” that could provide protection against SARS-CoV-2 even in case of mutations in the virus.


    Sorrento says it believes this antibody, which is labelled STI-1499, stood out among billions of candidates it has been screening from its extensive human antibody library for its ability to completely block the interaction of the SARS-CoV-2’s spike protein with a human cell target receptor. That means it prevents the virus from attaching to the host’s healthy cell, which is what leads to incubation and infection.


    The nature of the antibody’s efficacy means that Sorrento currently believes it will be the first antibody to be included in the cocktail it is developing, which will be made up of a large number of different antibodies that show efficacy in blocking the attachment of the spike protein, in order to provide multiple avenues of protection that are designed to remain effective even if the virus mutates in transmission from person to person, or within the same individual. One of the big outstanding questions that researchers are working on answering currently is just how mutagenic SARS-CoV-2 actually is, as many coronaviruses like the common cold show a tendency to mutate pretty quickly, rendering long-lasting cures and treatments difficult to develop.


    Sorrento’s COVID-SHIELD is meant to address this through a potent mix of different antibodies that provide protection against different strains of the virus, but the company says it also will be pursuing development of the STI-1499 antibody on its own as a dedicated, standalone therapy. The company is already in discussion with regulators about how to expedite development of that potential treatment, and is ramping its production capacity as well with the goal of producing as many as one million doses at the same time it pursues FDA approval for its use.


    It’s definitely worth cautioning that no treatment or vaccine is likely to be a “magic bullet” in treating SARS-CoV-2 or COVID-19, but this is still a promising development, and one to watch as it undergoes clinical trials and the therapeutic development and regulatory process.



    https://techcrunch.com/2020/05/15/sorrento-finds-a-coronavirus-antibody-that-blocks-viral-infection-100-in-preclinical-lab-experiments/
    Truly great and promising news in this time of dark and woe.
    As we --all-- want the world to return back to as much as was normal, as it was before this scourge came.
    Humanity must be able to interact without being fearful of each others's breath, touch or presence.
    What horror it would be if such could never again be!--Tyr
    18 U.S. Code § 2381-Treason Whoever, owing allegiance to the United States, levies war against them or adheres to their enemies, giving them aid and comfort within the United States or elsewhere, is guilty of treason and shall suffer death, or shall be imprisoned not less than five years and fined under this title but not less than $10,000; and shall be incapable of holding any office under the United States.

  4. Thanks Abbey, Russ thanked this post

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Debate Policy - Political Forums