Ivermectin, more evidence
70% decrees in death
Follow the evidence, wherever it leadsTreatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Databasehttps://bnf.nice.org.uk/medicinal-for...https://list.essentialmeds.orghttps://www.sciencedirect.com/science...https://www.sciencedirect.com/science...https://www.sciencedirect.com/journal...PurposeTo evaluate the difference in mortality,Patients treated with ivermectinPatients treated with remdesivir44 healthcare organizations and 68 million patients from US, January 1, 2020 and July 11, 2021Methods & MaterialsRetrospectively identified diagnosed adultsRecorded use of ivermectin, but not remdesivirRecorded use of remdesivir, but not ivermectinControlled for, comorbidities, and treatments that may affect COVID-19 survival outcomes: age, gender, race, ethnicity, nicotine use diabetes mellitus, obesity, chronic lower respiratory disease, ischemic heart diseases, tocilizumab, glucocorticoids, or ventilator use. Primary outcome assessed, mortalitySith significance assessed at p less than 0.05.Result41,608 patients who had COVID-19Treated with ivermectin n = 1,072Treated with remdesivir n = 40,536Ivermectin was associated with reduced mortality vs remdesivirOR 0.308p less than 0.0001.ConclusionIvermectin use was associated with decreased mortality in patients with COVID-19 compared to remdesivir. In the future, if more publications are published with the similar result to the current analyses, the certainty of evidence will increase.Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching (Brazil)https://www.cureus.com/articles/82162...BackgroundIvermectin has demonstrated different mechanisms of action, coronavirus infection and COVID-19-related comorbidities. Prophylaxis combined with the known safety profile of ivermectinStudy to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.Prospective, July 2020 and December 2020Inviting the entire population of Itajaí to a medical visit to enroll in the program,ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day. Study analysis consisted of comparing ivermectin users with non-users using cohortsResults223,128 citizens of Itajaí considered159,561 included in the analysis113,845 (71.3%) regular ivermectin users45,716 (23.3%) non-usersOf these4,311 ivermectin users were infected, (3.7% infection rate)3,034 non-users (6.6% infection rate)A 44% reduction in COVID-19 infection rateRisk ratio (RR), 0.56The regular use of ivermectin led to a 68% reduction in COVID-19 mortalityDeaths25 (0.8%) deaths in the ivermectin group79 (2.6%) among ivermectin non-usersRR, 0.32p less than 0.0001When adjusted for residual variables, reduction in mortality rate was 70%There was a 56% reduction in hospitalization rate44 in the ivermectin group99 in non ivermectin usersAfter adjustment for residual variables, reduction in hospitalization rate was 67%p less than 0.0001Conclusion In this large study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.
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